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489 As outlined in Section Errors in co- or post-translational protein modifications, tau NFT generation may be prefaced by tau hyperphosphorylation, leading to the adoption of an aberrant conformation and dissociation of tau from microtubules and conferring resistance to proteasomal and autophagic degradation

Oxidized LDL promotes atherosclerosis by altering endothelial NO production and upregulating the expression of leukocyte adhesion molecules [245]

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Lastly, placebo effects must also be considered