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The primary safety advantage is the lack of IGF-1 elevation

[PubMed] [Google Scholar] Lowry MH, McAllister BP, Jean JC, Brown LA, Hughey RP, Cruikshank WW, Amar S, Lucey EC, Braun K, Johnson P, Wight TN, Joyce-Brady M

10.1038/s41418-018-0124-5 66 LeiL.YuanJ.DaiZ.XiangS.TuQ.CuiX.et al (2024)

Magiera, A., Koodziejczyk-Czepas, J., Olszewska, M.A.: Antioxidant and Anti-Inflammatory effects of vanillic acid in human plasma, human neutrophils, and Non-Cellular models in vitro

Cenigaonandia-CampilloASerna-BlascoRGmez-OcaboLSolanes-CasadoSBaos-HerraizNPuerto-NevadoLet alVitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer