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However, further research is needed to establish a definitive relationship and understand the underlying mechanisms involved [58]

In recent years, cognitive dysfunction associated with type 2 diabetes mellitus (T2DM) has gained increasing attention and in-depth study ( Figure 1 2 Similarity between the kidney and brain 2.1 Both of kidney and brain share the similar endothelial damage under pathological condition The kidney serves as a crucial center for endothelial signaling

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The extent of pale areas without mucosal folds was recorded upon colon opening and after sacrifice as % of total area of the deprived colon segment (IC rats) or as % of total area of the reperfused colon segment (IC + RL rats)

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