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Antibiotics (Basel Switzerland) 10 (8)

Nakashima J, Tachibana M, Ueno M, Miyajima A, Baba S, Murai M

ADC linker optimization is an iterative process involving cycles of design, synthesis, analysis, and validation

Fe-doped and doxorubicin loaded HA@Cu 2-X S-PEG (PHCN) nanomaterials were designed as targeted Fe-PHCN@DOX nano-reactors to maximize the effect of ICD to promote antigen presentation thereby stimulating T cell activation, in addition, Fe-PHCN@DOX can reprogram M2 TAMs into M1 TAMs by alleviating tumor hypoxia, at the same time T cell activation is promoted through blockade of the PD-1/PD-L1 immunosuppressive pathway by anti-PD-L1 nanoantibodies thereby achieving effective antitumor effects (226)

[DOI] [PubMed] [Google Scholar] 10.Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J

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