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Concurrently, oscillatory shear stress activates the TRPM2 channel, mediating cytosolic Ca 2+ influx and NFAT signaling, which drives VSMC transition from a contractile to synthetic phenotype, promoting migration and proliferation and accelerating plaque formation [120,121]

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Includes both small molecules and macromolecules like biologics
J Clin Oncol 36 (29): 2926-2934, 2018
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Cloning and characterization of SLC26A6 , a novel member of the solute carrier 26 gene family
