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In addition, citrulline, a major precursor for endogenous arginine, supplementation has been shown to restore systemic arginine levels, improve airway NO production, and asthma control in individuals with obesity-related asthma [124]

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Although preclinical data are promising, we point out that insulin regulation and the metabolic response to a certain diet often differ between mice and humans

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Reduced BDNF availability may in turn limit TrkB phosphorylation and attenuate downstream PI3K/Akt and MAPK/ERK signaling (Numakawa and Kajihara, 2023)