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Possible role of PHD inhibitors as hypoxia-mimicking agents in the maintenance of neural stem cells' self-renewal properties

Based on their structure, spider venom PLDs can be assigned to class I, featuring three cysteine residues, two forming a disulfide bridge, and five residues in an extended flexible loop or class II, which features four cysteine residues forming two disulfide bridges, one connecting the catalytic region to a flexible loop and reducing the size of the active site cavity (Murakami et al., 2006

When mice are deficient in SELENOT, hyperactive behaviors are also noticed, such as higher mean velocity and lower immobile times (Castex et al., 2016)

PMID: 40882907 Biomater Res Albumin Nanocages with Methotrexate and Chondroitin Sulfate as a Dual pH/GSH-Responsive Tumor Targeting Nanomedicine for Synergistic Cancer Therapy

(E) Surface markers of PDLSCs assessed by flow cytometry analysis

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