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Reducing application frequency or concentration can minimize irritation for sensitive individuals

Forde et al., 2019

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50 Local SDF-1 release increased the recruitment of systemically infused bone marrow-derived MSCs by 700% in a mouse model of myocardial infarction (MI), 51 suggesting that cartilage repair scaffolds releasing SDF-1 may perform synergistically with MSCs from marrow recruitment or intra-articular injections
Only in such situations, it is advisable to take injections of Vitamin B12