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In aqueous environments, the E isomer is the most stable, while the Z isomer is approximately 0.8 kcal/mol higher in Gibbs free energy, maintaining continuous equilibrium between the two forms and complicating their separation

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The present study also found individual differences in OSD, distributed over a range of about 2 h

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Rhodopsin, for example, uses the conversion of 11-cis -retinal to all-trans -retinal for this purpose

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