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Data from this pilot will provide the basis for power calculation for a full-scale trial

Impairment of fertility: In sub-chronic/chronic toxicity studies, testicular degeneration/atrophy or spermatogenesis abnormalities and a decrease in testes weight were reported in adult rats and dogs after oral administration starting at doses of 1250 mg/kg/day and 150 mg/kg/day, respectively

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In dermal fibroblasts, the peptide increases cell proliferation rates by 20% while dramatically enhancing their synthetic activity

While no significant within-group changes were observed in STAT3, TGF-1 in the L-carnitine group, STAT3 levels increased significantly in the control group compared to baseline