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The threshold at which this association has been observed is serum levels over 813 pg/mL (600 pmol/L)

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Reduces Dark Spots: The combination of Glutathione and Tranexamic Acid effectively reduces the appearance of dark spots and blemishes

doi: 10.1016/s0300-483x(02)00071-9

Similar concerns apply to phosphodiesterase-5 inhibitors (medications like sildenafil) and L-arginine supplements that also influence nitric oxide signaling