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J Gerontol 11:298300 [DOI] [PubMed] [Google Scholar] Harman D (2009) Origin and evolution of the free radical theory of aging: a brief personal history, 19542009

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it is not stable at dilute working concentrations in aqueous solution

The complexity of bioactive compounds in medicinal plants, variability in preparation processes, and the unpredictability of their absorption, distribution, metabolism, and excretion in the body collectively constitute the primary translational bottlenecks