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In colorectal cancer, NSUN2 enhances the stability of PHGDH mRNA through m5C methylation, thereby activating the SSP, increasing the intracellular NADH/NAD + and NADPH/NADP + ratios, reducing ROS levels and apoptosis, and promoting tumor cell survival and proliferation (105)

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Research on osteosarcoma treatment has revealed that DDRGK domain-containing protein 1 (DDRGK1) inhibits the ubiquitin-proteasome-mediated degradation of NRF2 by competitively binding to Keap1