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Therefore, future studies should incorporate randomized, double-blind, placebo-controlled designs to rigorously validate the efficacy of topically administered liquid NAC and rule out placebo effects

Competing interests The authors declare that they have no competing interests

Complete pharmacokinetic profiles (absorption, distribution, metabolism, excretion) have not been fully characterized in humans

Therefore, dietary iodine intake, primarily dependent on fish consumption, is frequently below recommended levels in a large part of the population, and supplementation is necessary

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