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These peptides released by MSCs interact with receptors on target cells, triggering or suppressing specific biological processes that influence the bodys overall condition
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In addition, in vitro experiments involving the stimulation of human retinal endothelial cells and HUVECs with recombinant ESM1 demonstrated the activation of MAPK (ERK, JNK and p38) signaling pathways associated with angiogenesis (47,58), which further confirms the relationship between ESM1 and the MAPK signaling pathway
[DOI] [PubMed] [Google Scholar] 35.Reis FM, Blasio AMD, Florio P, et al
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Progesterone acts as a regulator it prevents testosterone from converting excessively into estrogen or DHT
