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In vivo PK profiling of IACS-16898 in mice To calculate PK parameters, SCID mice were dosed with IACS-16898 via oral administration at 50 mg/Kg, BID, for 5 days
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The AC group tended to exhibit longer escape latencies than the other groups
Li SY, Jia YH, Sun WG, Tang Y, An GS, Ni JH, Jia HT
However, compared to M2 macrophages, M1 macrophages exert higher resistance to pharmacologically induced ferroptosis in vivo
