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ER stress can modulate the phosphorylation of eIF2, leading to the attenuation of protein synthesis, whereas the subsequent activation of ATF4/CHOP can increase protein synthesis, triggering apoptosis

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Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells

Ma W, Westmoreland JW, Gordenin DA, Resnick MA

doi: 10.1016/j.arbres.2017.02.001

The burden increases with exposure to the sun, smoking, eating the wrong foods, etc
