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While PUFA and oxygen are directly involved in the reaction, iron plays a critical role in intensifying the process

[DOI] [PMC free article] [PubMed] [Google Scholar] Soares NP, Campos KKD, Pena KB, Bandeira ACB, Talvani A, Silva ME, et al

Semaglutide GLP-1 Metabolic Peptide Therapy FDA-Approved for Weight Loss & Metabolic Regulation Semaglutide is a once-weekly GLP-1 peptide that improves appetite control, stabilizes blood sugar, and supports long-term weight reduction

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Nuclear receptors such as peroxisome proliferator-activated nuclear receptors (PPAR) play a key role in hepatic lipid metabolism, however results on association of PPAR and severity of NAFLD have been variable (75)

Ethics declarations Ethics approval and consent to participate All animal studies were accredited by the Institutional Ethics Committee and followed the requirements for the care and use of laboratory animals of the Hangzhou Institute of Medicine (HIM) of the Chinese Academy of Sciences (AP2025-11-0636)