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doi: 10.3389/fcell.2020.583850 Received 15 July 2020 Accepted 31 August 2020 Published 18 September 2020 Volume 8 - 2020 Edited by Vadivel Ganapathy, Texas Tech University Health Sciences Center, United States Reviewed by David Thwaites, Newcastle University, United Kingdom

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In BAT upregulated genes included SLC6A8 and GATM in creatine-dependent thermogenesis (Kazak et al, 2015), Ryr2 and SERCA2 in calcium cycling (Ikeda et al, 2017