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While these model systems provide valuable insights into liver function and drug metabolism, they fail to mimic the intricate three-dimensional (3D) architecture, cellular heterogeneity, and zonation observed in the native liver

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Post-mortem studies of the autistic brain samples showed abnormal changes in the steady-state levels of complexes I-IV in the cingulate gyrus, cerebellum, thalamus, and temporal and frontal cortex [79, 80, 86, 122]

As a result, symptomatic -thalassemia is relatively common in Asian populations and rare in African populations