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In some cases, the allostatic load 28 can exceed what the neuroendocrine response (aka the HPA axis response) is capable of managing, which is referred to as allostatic overload

Adams MA

Melum et al., 2011

doi: 10.1073/pnas.0610117104

Nutrition deficiency promotes apoptosis of cartilage endplate stem cells in a caspase-independent manner partially through upregulating BNIP3
