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Glycogen synthase kinase 3 (GSK 3), a multifunctional serine and threonine kinase, plays a critical role in a variety of cellular activities, including signaling transduction, protein and glycogen metabolism, cell proliferation, cell differentiation, and apoptosis

Engstrom, Preclinical and clinical evaluation of broccoli supplements as inducers of glutathione S-transferase activity, Clin

35 (Web Server issue), W407W410

Ghaw et al., 2024

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

It has been reported that in BRAF V600E PTC, ACC2 expression is significantly lower compared with BRAF WT PTC, thus downregulates lipogenesis and promotes FAO [134], indicating different metabolic tendencies in diverse genotypes of TC