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Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

While a major concern about the use of immunotherapy in PD treatment is whether antibodies will have significant brain penetration to achieve sufficient target engagement, these engineered fragments might circumvent that issue, as they have higher brain penetrance and faster clearance

Bruchard, M

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Licochalcone a-induced human gastric cancer bgc-823 cells apoptosis by regulating ros-mediated mapks and Pi3k/Akt signaling pathways