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The upregulation of these genes affects the expression of upstream/downstream genes, leading to a remarkable disturbance of cancer-associated signaling pathways (296) (Supplementary Figure S2)

Although not much evidence is found, it is proposed that carotenoids can also display pro-oxidant effects especially through autoxidation in the presence of high concentrations of oxygen-forming hydroxyl radicals [54]

Thus, the half-life of superoxide, although very short at high concentrations (e.g., 0.05 seconds at 0.1mM) is actually quite long at low concentrations (e.g., 14 hours at 0.1 nM)

GHK-Cu can directly scavenge harmful reactive oxygen species (ROS), thereby mitigating oxidative stress

Conversely, diets high in saturated fats and simple sugars may reduce bacterial diversity and favor the expansion of proinflammatory species

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