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Description
BI-3663 is a highly selective PTK2/FAK PROTAC (DC50 = 30 nM) with a Cereblon E3 ligase ligand capable of degrading PTK2, with an IC50 value of 18 nM
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While the approaches targeting these pathways form the foundation of standard PH treatment, the challenge remains to develop more effective therapeutic strategies
Conventional therapeutic approaches, including aminosalicylates, corticosteroids, immunosuppressants, and biological agents, face significant limitations including premature drug release, systemic toxicities, narrow therapeutic windows, and inadequate colonic accumulation
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It hydrates, soothes, and revives tired eyes for a fresh, youthful appearance
