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Especially relevant to patients is that the first two days per week of exercise did not seem to translate to slower progression over time

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doi: 10.1105/tpc.12.1.97

However, synthetically lethal effects are observed in yeast containing a single point mutant in the Pol3 CysB motif with essential components (DRE2, NBP35, and TAH18) of CIA complex ( 55 Fe experiment, UVVis, and electron paramagnetic resonance (EPR) spectroscopic studies proved that the CysB motifs of all B-family DNA polymerases coordinate ISCs rather than Zn 2+ (Netz et al., 2011