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While PEGylation improves systemic circulation by reducing clearance, it does not inherently facilitate BBB penetration and may even hinder interaction with the endothelial surface

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Cholesterol is all the same whether its attached to an LDL or an HDL particle, explains Dr

The fact that genetic and environmental factors are involved does not make it any easier either [42,43,44]

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It is an infrequently symptomatic illness, until years later