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MBio 11(1):e03256-e3319 Backert S, Selbach M (2005) Tyrosine-phosphorylated bacterial effector proteins: the enemies within

By properly balancing endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) signaling, BPC-157 down-regulates destructive pro-inflammatory cytokines without neutralizing the acute, necessary oxidative signals needed to command cellular division 6
This finding has important safety implications, as elevated IGF-1 levels associated with full GH therapy raise concerns about increased cancer risk, particularly for individuals with pre-existing malignancies or strong family histories

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