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This gut-brain axis dysfunction perpetuates a vicious cycle where systemic inflammation drives neurological symptoms, and neurological stress further degrades the integrity of the intestinal barrier, leading to a cascade of multi-systemic symptoms

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The TGF-1/Smad3 pathway is a key driver of this process, inducing the expression of fibrotic markers such as -SMA and collagen I, promoting interstitial remodeling

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The authors wish to thank Michael R

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Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia

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