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Data from 270 patients showed that CKD had a response rate of 52%, while MAD had a response rate of 34%, suggesting that CKD may be more effective in some cases

Niacinamide also is thought to inhibit the transfer of melanin from the melanocytes to keratinocytes to decrease hyperpigmentation of skin

doi: 10.3389/fonc.2022.913669 Received 06 April 2022 Accepted 11 May 2022 Published 03 June 2022 Volume 12 - 2022 Edited by Jianming Li, Soochow University, China Reviewed by Yang Li, Shanghai University of Traditional Chinese Medicine, China

Importantly, P4-induced slowing of hypothalamic GnRH pulse frequency during the luteal phase alters downstream pituitary signaling dynamics, reinforcing the cyclical alternation between estrogen-dominant and P4-dominant endocrine states [26]