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Cancer 21 , 89103 (2021)

1991 Sep

It is a progressive disease and, if left untreated, may lead to liver disease, central nervous system dysfunction and death[2,3]

H 2 O 2 , for instance, exerts its influence by inhibiting autophagy-related protein 4 (ATG4), thereby bolstering lipidated microtubule-associated protein 1 light chain 3-II (LC3-II levels), which facilitates LC3-II binding to autophagosomes and promotes p62 oligomerization, enhancing autophagosome biogenesis [116, 117]

In addition, a trend toward delayed progression to kidney failure and the need for dialysis was observed in the probiotic group compared with the placebo group at a 3-year follow-up

Similarly, Insulin-like growth factor binding protein 7 (IGFBP7) deletion in the zebrafish NAFLD model significantly increased the expression of the nuclear receptor coactivator 4 (NCOA4), increased NCOA4-mediated ferritin autophagy (ferritinophagy), maintained intracellular iron homeostasis, and reduced the occurrence of hepatocyte ferroptosis [140]