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Given that GSH has a molecular weight similar to that of amino acids, a plausible scenario is that when plants experience mechanical damage or insect attack, a large volume of GSH from the intracellular region may surge into the apoplastic region, inducing calcium influx by activation of the GLR3.3 ion channel

This indicates the importance of the p53 TAD2 region in FOXO4 FHD binding

Kong CS, Kim JA, Qian ZJ, Kim YA, Lee JI, Kim SK, et al

The mechanism might involve direct antiemetic effects of B12, or it might reflect improved overall metabolic function when vitamin status is maintained

doi: 10.1002/(sici)1096-8628(19980428)77:1 3.0.co;2-o

The pro-tumorigenic effect of iso-LCA observed in their models was demonstrated to be dependent on NK cells, as NK cell depletion abrogated the difference in tumor growth between control and iso-LCA-treated mice (44)