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Data from Latin America is missing

Butonitazene, isotonitazene, protonitazene were mainly fragmented to desethylated (up to 50%) and dealkylated (3%) parts in vitro incubations (Table 7

p53-mediated bidirectional regulatory mechanism The tumor suppressor protein p53 intricately regulates cell fate through its dual role in promoting and inhibiting ferroptosis (127,128)

As an important part of metabolic reprogramming in the tumors, reprogramming of glutamine metabolism is considered to have pleiotropic effects on cellular functions, such as macromolecule synthesis, energy generation, mTOR activation, maintenance of reactive oxygen species (ROS) balance and anti-tumor acidic microenvironment

The neuroendocrine system facilitates homeostasis by means of secretion and transport of hormones to target sites via the bloodstream, whereas the nervous system allows rapid neuronal communication of information between different regions of the body via the brain, spinal cord and nerves

These pathways synergize: activation of one primes the cell to respond more strongly to the other