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Dec 2019;119(12):2053-2063

COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine

To specifically eliminate sympathetic nerves, we bred Th -cre mice with ROSA26i-DTR mice to generate Th -DTR mice, which ablated TH + neurons and nerves upon diphtheria toxin (DT) administration (Fig

Our current understanding is that emodin can exert therapeutic effects through multiple pathways, including antioxidant, anti-inflammatory, and inhibition of CYP450

Hanauska D

GHS-R knockout mice have the same food intake and body composition as their wild-type littermates, although their body weight is decreased in comparison