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Additionally, changes in cortical excitability and synaptic efficacy can impair the transmission of motor commands

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Furthermore, a double mutant lacking the operon encompassing both ahpD and spr0371 genes demonstrated enhanced resistance to H 2 O 2 concentrations of 9, 18, and 37 mM in the R6 strain [29]

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GRIK4 is particularly noteworthy, due to its selective expression in the cortex and striatum, where it plays a role in sensory motor gating and protection against excitotoxicity (Lu et al., 2020)