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[DOI] [Google Scholar] 117.Raleigh DR, et al
Tatiana Lapa, an aesthetic doctor and founder of Drs Tatiana + Rishi Advanced Aesthetics, says your skin can be one of the indicators of a B12 deficiency: Symptoms might include a pale or jaundiced appearance, and in more severe cases, individuals might develop hyperpigmentation or a rash
Adding semaglutide to this situation creates a double hit on absorption capacity

The liver stores significant amounts of B12, providing a reserve that can last several months to years, depending on the individual's metabolic needs and the severity of prior deficiency
Hypothesis 2 Smoother appetite curve GLP-1 satiety and amylin satiety are partially out-of-phase amylin signaling is more meal-bound (postprandial), GLP-1 satiety is more sustained

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
