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Inhalation of nitrous oxide (N 2 O) as an anesthetic has long been known to cause megaloblastic anemia and bone marrow suppression in patients [62]

doi: 10.1016/j.trac.2023.117327 [DOI] [Google Scholar] 34.Wang CY, Wen L, Wang K, et al

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Over the past two decades, the prevalence has risen significantly, reaching 37.8% since 2016

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As noted, both EPO and MBP induce noncytolytic, dose-dependent 5-hydroxytryptamine release from platelets.82 Binding of EPO to neutrophils reversibly inhibits EPO peroxidase activity but increases neutrophil aggregation and adhesion to endothelial cells.83 EPO binding to microbes, including Staphylococcus aureus , greatly potentiates their killing by phagocytes