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10.1016/j.jnutbio.2008.12.007 32

Pulmonary Vasodilator Therapy Is Associated with Decreased Mortality in Patients with Chronic Lung Disease and Severe Pulmonary Hypertension

The most effective diagnosis and treatment continue to evolve

Some of these problems include neurological disorders, brain atrophy, demyelination, delayed cognitive development and growth, mental retardation, lack of emotional and communicative responses, lack of smiling and willingness to play, extreme fatigue, vomiting, tremors and convulsions, gait and motor coordination disorders, severe megaloblastic anemia, thrombocytopenia, pancytopenia, which can lead to coma, respiratory failure, and death

Next to the initial model substrate D1 bearing a 5-aminohexyl moiety, three phosphorothioate oligonucleotides (including multiple LNA modifications) bearing different 5-modifications were investigated

2021;184:10001016.e1027