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NICE-approved weight management interventions include: Dietary and lifestyle modification first-line approach for all patients Orlistat licensed medication for obesity (BMI 30 or 28 with comorbidities) GLP-1 receptor agonists including semaglutide (Wegovy) per NICE TA875 and liraglutide (Saxenda) with restrictions per NICE TA664, for specific patient groups Bariatric surgery for severe obesity meeting strict criteria The NHS emphasises that sustainable weight loss requires behavioural change, nutritional education, and increased physical activity

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In an unusual move, Judge Cote sent two questions to the Food and Drug Administration: Whether acetaminophen products should carry the proposed warning suggested by the plaintiffs counsel

doi: 10.1371/journal.pone.0048515 132 TassoneA.MeringoloM.PonterioG.BonsiP.SchirinziT.MartellaG