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Consequently, combination strategies that concurrently target metabolic adaptation and bypass signaling are emerging as effective approaches to enhance efficacy and delay resistance
This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

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moellendorffii , we conclude that these genes have rapidly and dramatically expanded between bryophytes and lycophytes

Important components of the cellular machinery controlling these processes are under transcriptional, translational, and posttranslational control by estrogen, and in vivo studies in humans have demonstrated sex-specific differences (49)

Arginine depletion inhibits the dephosphorylation of the actin-binding protein cofilin, thereby impairing immunological synapse formation and T cell activation [240,241,242]
