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The high doses of drugs given led to higher rates of AEs than expected in clinical practice

Upon binding to the receptors, cascades of tyrosine and serine kinases are stimulated to facilitate growth or metabolism

Archived from the original on March 29, 2018

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REGISTRATION: URL: Unique identifier: NCT05567796

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5