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Description
Currently, targeting ferroptosis can reverse chemotherapeutic resistance, which mainly consists of three pathways related to the ferroptosis mechanism, typically the GPX4-regulated pathway, the iron metabolism pathway, and the lipid metabolism pathway (42)

The mouse brains from different groups were collected on day 7 post-treatment for western blot and immune fluorescence staining to exam the NETs and inflammation level
More critically, upon penetrating the BBB, ROS directly damage neurons and glial cells

Notably, LPS stimulation compromised mitochondrial energy metabolism in macrophages, as evidenced by a 65.7% decrease in ATP content, 33.2% decrease in NAD + content, and 27.5% reduction in the NAD/NADH ratio compared to the control group
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Convenience For those with busy lifestyles, monthly B12 injections can be a simple, effective way to maintain optimal levels without requiring daily supplementation
