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Braga, 2011

Data analysis was performed by an investigator blinded to the experimental conditions

Oncotarget 9 (22), 1584715859

Cell Metab 29:10031011.e4 Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Snchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T (2017) Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

Cysteine can be synthesized from methionine ( via transsulfuration) but can also be imported into the cell as cystine (Cys2, the oxidized form of cysteine) through a sodium-independent antiporter called system x c -

Furthermore, extended reaction times improve the detection limits of protonated hydrazone derivatives, whereas combining the conventional MALDI matrix CHCA with DNPH/DMNTH reactive matrices enhances both the sensitivity and detection limits