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Pathological jaundice appears within the first 24 hr of life and is more likely to lead to the development of kernicterus/bilirubin encephalopathy

By limiting glycine availability in the synaptic and perisynaptic space, GlyT1 helps maintain submaximal occupancy of the co-agonist binding site, providing a mechanistic basis for the pharmacological inhibition of this transporter as a strategy to enhance NMDA receptor function

systematically revealed the dynamic changes in the gut microbiota induced by high-fat feeding and found that gut bacteria produce superoxide anions, which induce damage to intestinal epithelial cells, leading to intestinal barrier dysfunction and exacerbating downstream hepatic steatosis (107)

Timmerman LA, Holton T, Yuneva M, Louie RJ, Padr M, Daemen A, Hu M, Chan DA, Ethier SP, van't Veer LJ, Polyak K, McCormick F, Gray JW

Regarding safety, short-term use (less than 1 month) of melatonin at recommended doses (typically 0.15 mg to 12 mg daily) is generally well-tolerated