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They also noted that a higher dose that was still within a fairly typical range seemed to show a greater benefit than a lower dose

Kotrys, A

All patients were administered the same dose of 5 g IV hydroxocobalamin, diluted in 200 mL of 0.9% sodium chloride solution, infused over 15 minutes

In order to overcome the limitation, ultrasound stimulated piezoelectric nanoparticle activation came in existence, which is able to generate electricity upon exposure of mechanical deformation and serve as a promising tool in targeted stimulation of cells and tissues [219]