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observations on the maintenance of a normal hematologic status and on the occurrence of combined system disease at the end of one year

doi.org/10.1038/nature03000 Dalmasso, G., et al

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However, observational studies cannot exclude the possibility that elevated homocysteine levels may be associated with confounding variables such as unhealthy lifestyles and other established risk factors, rather than being causally related to vascular disease

Consistency is important