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Objective response rates (ORR) are low in MUM, ranging from 5% with ipilimumab (CTLA-4 inhibitor), 3.6% with anti-programmed cell death 1 (PD-1) antibodies, 1021% with combination ipilimumab and nivolumab (ipi/nivo), and 7.7% with combination relatlimab and nivolumab [79,80,81,82,83,84,85,86,87,88]

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