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Elle est gnralement plus leve chez les hommes, la mnopause, et chez les personnes ges

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Tableau : Effets indsirables connus Systme d'organe Effets indsirables Frquence Affections du systme immunitaire Raction allergique : prurit, urticaire, eczma, rythme, dme pouvant tre svre Indtermin Choc anaphylactique Rare Affections gastro-intestinales Diarrhe transitoire Indtermin Affections de la peau et du tissu sous-cutan Acn Indtermin Affections du rein et des voies urinaires Coloration rouge des urines (correspondant l'limination urinaire de la vitamine B12)