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This was followed by the inhibition of CI by rotenone (2 M) to measure the S-pathway (CII) in the uncoupled state

This study reports computational screening based on the MOR structure, allowing the discovery of novel agonist chemotypes unrelated to known opioids and leading to a G i -biased drug with unusual and promising biological properties towards safer analgesics
Supplementary material The Supplementary Material for this article can be found online at: Abbreviations IBS, Irritable bowel syndrome

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doi:10.1016/j.smrv.2018.03.004 Dominguez JE, Krystal AD, Habib AS