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Both touch MC4R, but PT-141 is the selective MC4R agent studied for sexual desire, while MT-II binds broadly across MC1R/MC3R/MC4R/MC5R, with pigmentation (MC1R) as its signature

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Engages the brain's desire centers for a natural response

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Vollmer RT, Seigler HF (2000) A model for pretest probability of lymph node metastasis from cutaneous melanoma

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Structure-activity relationships of melanotropin peptides

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